Clinical Features, Long-Term Prognosis, and Clinical Management of Genotype-Negative Long QT Syndrome Patients.

doi:10.1016/j.jacep.2024.07.022

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Clinical Features, Long-Term Prognosis, and Clinical Management of Genotype-Negative Long QT Syndrome Patients.

JACC. Clinical electrophysiology - 1 Dec 2024

Shimamoto Keiko, Dagradi Federica, Ohno Seiko, Spazzolini Carla, Crotti Lia, Giovenzana Fulvio L F, Musu Giulia, Pedrazzini Matteo, Kusano Kengo, Takegami Misa, Nishimura Kunihiro, Horie Minoru, Aiba Takeshi, Schwartz Peter J

Abstract excerpt

BACKGROUND: Approximately 15% to 20% of patients clinically diagnosed with long QT syndrome (LQTS) are genotype-negative (GEN-). Whether they have a different arrhythmic risk or should be managed differently remains unclear, often leading to incomplete treatment. OBJECTIVES: The purpose of this study was to compare clinical aspects of GEN- and genotype-positive (GEN+) LQTS patients. METHODS: We retrospectively...

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Clinical Features, Long-Term Prognosis, and Clinical Management of Genotype-Negative Long QT Syndrome Patients.

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