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Article

In-silico analysis predicts disruption of normal angiogenesis as a causative factor in osteoporosis pathogenesis.

BMC genomic data - 8 Oct 2024

James Remya, Subramanyam Koushik Narayan, Payva Febby, E Amrisa Pavithra, Tv Vineeth Kumar, Sivaramakrishnan Venketesh, Ks Santhy

Abstract excerpt

Angiogenesis-osteogenesis coupling is critical for proper functioning and maintaining the health of bones. Any disruption in this coupling, associated with aging and disease, might lead to loss of bone mass. Osteoporosis (OP) is a debilitating bone metabolic disorder that affects the microarchitecture of bones, gradually leading to fracture. Computational analysis revealed that normal angiogenesis is disrupted...

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Computational Biology
Computer Simulation
Neovascularization, Pathologic
Osteoporosis
Osteoporosis, Postmenopausal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39379846
DOI: 10.1186/s12863-024-01269-z
PMCID: PMC11460074

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