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A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20

2 Oct 2024

Abstract excerpt

Usutu virus (USUV) and West Nile virus (WNV) are two closely related emerging mosquito-borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe neurological disorders in humans. Both viruses are efficiently suppressed by type I interferon (IFN), which interferes with viral replication, dissemination, pathogenesis and transmission. Here, we show that the replication of USUV and WNV...

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PMID: 39358425
DOI: 10.1038/s41467-024-52870-w

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