BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial.

doi:10.1038/s41416-024-02832-2

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BRCA-DIRECT digital pathway for diagnostic germline genetic testing within a UK breast oncology setting: a randomised, non-inferiority trial.

British journal of cancer - 1 Nov 2024

Torr Bethany, Jones Christopher, Kavanaugh Grace, Hamill Monica, Allen Sophie, Choi Subin, Garrett Alice, Valganon-Petrizan Mikel, MacMahon Suzanne, Yuan Lina, Way Rosalind, Harder Helena, Gold Rochelle, Taylor Amy, Gabe Rhian, Lucassen Anneke, Manchanda Ranjit, Fallowfield Lesley, Jenkins Valerie, Gandhi Ashu, Evans D Gareth, George Angela, Hubank Michael, Kemp Zoe, Bremner Stephen, Turnbull Clare

Abstract excerpt

BACKGROUND: Genetic testing to identify germline high-risk pathogenic variants in breast cancer susceptibility genes is increasingly part of the breast cancer diagnostic pathway. Novel patient-centred pathways may offer opportunity to expand capacity and reduce turnaround time. METHODS: We recruited 1140 women with unselected breast cancer to undergo germline genetic testing through the BRCA-DIRECT pathway (which...

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PMID: 39349619
DOI: 10.1038/s41416-024-02832-2
PMCID: PMC11519354

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