An eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients With Metastatic Cancers: Protocol for a Randomized Trial.

doi:10.2196/72515

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An eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients With Metastatic Cancers: Protocol for a Randomized Trial.

JMIR research protocols - 25 Aug 2025

Lee Kimberley T, McLeod Briana, Egleston Brian, Brown Sarah, Howe Sarah, Fetzer Dominique, Gutstein Lauren, Cacioppo Cara, Clark Dana, Domchek Susan M, Ebrahimzadeh Jessica, Falcone Dana, Ofidis Demetrios, Griffin Hannah, Mim Rajia, Hernandez Santina, Fleisher Linda, Karpink Kelsey, Selmani Enida, Tahsin Aysha, Wagner Lynne, Weinberg Michelle, Yi-Wen Kuang, Wood Elisabeth, Bradbury Angela R

Abstract excerpt

BACKGROUND: Germline BRCA1 and BRCA2 testing is a standard evidence-based practice, with established risk reduction and cancer screening guidelines for genetic carriers. With Food and Drug Administration approval for poly (adenosine diphosphate ribose) polymerase (PARP) inhibitors in patients with metastatic breast, ovarian, pancreatic, and prostate cancer, there is an additional therapeutic rationale for testing...

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PMID: 40853717
DOI: 10.2196/72515
PMCID: PMC12417906

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