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Article

Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites.

Oncology research - 1 Jan 2024

Wang Zhiguo, Li Kunlin, Lu Conghua, Feng Mingxia, Lin Caiyu, Yin Guofang, Luo Dan, Liu Wenyi, Jin Kaiyu, Dou Yuanyao, Wu D I, Zheng Jie, Zhang Kejun, Li L I, Fan Xianming

Abstract excerpt

Background: Metformin has pleiotropic effects beyond glucose reduction, including tumor inhibition and immune regulation. It enhanced the anti-tumor effects of programmed cell death protein 1 (PD-1) inhibitors in serine/threonine kinase 11 (STK11) mutant non-small cell lung cancer (NSCLC) through an axis inhibition protein 1 (AXIN1)-dependent manner. However, the alterations of tumor metabolism and metabolites...

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Identifiers

PMID: 39308524
DOI: 10.32604/or.2024.052664
PMCID: PMC11413838

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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