The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis.

doi:10.1159/000541447

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Article

The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis.

Respiration; international review of thoracic diseases - 1 Jan 2025

Yilmaz Yegit Cansu, Ergenekon Pinar, Yanaz Mürüvvet, Ozturk Akar Nezafet, Toktas Yavuz Fatma, Molla Kafi Hale, Çollak Abdülhamit, Bal Nilüfer, Gedik Toker Özge, Meral Özge, Ataş Ahmet, Çetin Kara Halide, Ayhan Yetkin, Guliyeva Aynur, Yuksel Kalyoncu Mine, Selçuk Balcı Merve, Karabulut Şeyda, Taştan Gamze, Uzunoglu Burcu, Karasu Nesibe, Oruc Yesim, Acar Melda, Yumuşakhuylu Ali Cemal, Dogan Remzi, Gozen Tan Emine Deniz, Ata Pinar, Kılınç Sakallı Ayşe Ayzıt, Girit Saniye, Cakir Erkan, Gokdemir Yasemin, Erdem Eralp Ela, Ciprut Ayca, Karakoc Fazilet, Karadag Bulent

Abstract excerpt

INTRODUCTION: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF. MATERIALS/METHODS: The multicenter study included 121 pwCF aged between 5...

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PMID: 39299224
DOI: 10.1159/000541447

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