Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections.

doi:10.1038/s41467-024-51924-3

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Article

Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections.

Nature communications - 18 Sept 2024

Nooruzzaman Mohammed, Johnson Katherine E E, Rani Ruchi, Finkelsztein Eli J, Caserta Leonardo C, Kodiyanplakkal Rosy P, Wang Wei, Hsu Jingmei, Salpietro Maria T, Banakis Stephanie, Albert Joshua, Westblade Lars F, Zanettini Claudio, Marchionni Luigi, Soave Rosemary, Ghedin Elodie, Diel Diego G, Salvatore Mirella

Abstract excerpt

We investigated the impact of antiviral treatment on the emergence of SARS-CoV-2 resistance during persistent infections in immunocompromised patients (n = 15). All patients received remdesivir and some also received nirmatrelvir-ritonavir (n = 3) or therapeutic monoclonal antibodies (n = 4). Sequence analysis showed that nine patients carried viruses with mutations in the nsp12 (RNA dependent RNA polymerase),...

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PMID: 39294134
DOI: 10.1038/s41467-024-51924-3
PMCID: PMC11411086

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