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Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease

18 Sept 2024

Abstract excerpt

BACKGROUND: Colony-stimulating factor 1 receptor (CSF1R)-dependent monocytes and macrophages are key mediators of chronic graft-versus-host disease (GVHD), a major long-term complication of allogeneic hematopoietic stem-cell transplantation. The CSF1R-blocking antibody axatilimab has shown promising clinical activity in chronic GVHD. METHODS: In this phase 2, multinational, pivotal, randomized study, we evaluated...

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PMID: 39292927
DOI: 10.1056/nejmoa2401537

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