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Article

A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice

19 Feb 2023

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36805082
DOI: 10.1016/j.ymthe.2023.02.015

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Related research

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A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome micePMID 36805082Read ↗

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA.Semantic proximity Read ↗

CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in miceSemantic proximity Read ↗

A Human Angelman Syndrome Class II Pluripotent Stem Cell line with Fluorescent Paternal <i>UBE3A</i> ReporterSemantic proximity Read ↗

Truncation of Ube3a-ATS Unsilences Paternal Ube3a and Ameliorates Behavioral Defects in the Angelman Syndrome Mouse ModelSemantic proximity Read ↗

Transcriptional reprogramming restores UBE3A brain-wide and rescues behavioral phenotypes in an Angelman syndrome mouse model.Semantic proximity Read ↗

Epigenetic editing alleviates Angelman syndrome phenotype in mice by unsilencing paternal Ube3aSemantic proximity Read ↗

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