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Article

Loss of Heterozygosity and Mutations in the RAS-ERK Pathway Genes in Tumor Cells of Various Loci in Multiple Myeloma.

International journal of molecular sciences - 30 Aug 2024

Soloveva Maiia, Solovev Maksim, Risinskaya Natalya, Nikulina Elena, Yakutik Igor, Biderman Bella, Obukhova Tatiana, Chabaeva Yulia, Kulikov Sergej, Sudarikov Andrey, Mendeleeva Larisa

Abstract excerpt

Multiple myeloma (MM) is a disease characterized by spatiotemporal heterogeneity of tumor clones. Different genetic aberrations can be observed simultaneously in tumor cells from different loci, and as the disease progresses, new subclones may appear. The role of liquid biopsy, which is based on the analysis of tumor DNA circulating in the blood plasma, continues to be explored in MM. Here, we present an analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 39273371
DOI: 10.3390/ijms25179426
PMCID: PMC11394882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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