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Article

Predicting BRCA mutation and stratifying targeted therapy response using multimodal learning: a multicenter study.

Annals of medicine - 1 Dec 2024

Li Yi, Xiong Xiaomin, Liu Xiaohua, Xu Mengke, Yang Boping, Li Xiaoju, Li Yu, Lin Bo, Xu Bo

Abstract excerpt

BACKGROUND: The status of BRCA1/2 genes plays a crucial role in the treatment decision-making process for multiple cancer types. However, due to high costs and limited resources, a demand for BRCA1/2 genetic testing among patients is currently unmet. Notably, not all patients with BRCA1/2 mutations achieve favorable outcomes with poly (ADP-ribose) polymerase inhibitors (PARPi), indicating the necessity for risk...

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Source

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Identifiers

PMID: 39258876
DOI: 10.1080/07853890.2024.2399759
PMCID: PMC11391871

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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