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Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma

1 Jul 2009

Abstract excerpt

Gene expression profiling has revealed that the gene coding for cannabinoid receptor 1 (CB1) is highly up-regulated in rhabdomyosarcoma biopsies bearing the typical chromosomal translocations PAX3/FKHR or PAX7/FKHR. Because cannabinoid receptor agonists are capable of reducing proliferation and inducing apoptosis in diverse cancer cells such as glioma, breast cancer, and melanoma, we evaluated whether CB1 is a...

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PMID: 19509271
DOI: 10.1158/1535-7163.mct-08-1147

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