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Synthesis of Chalcones, Screening In silico and In vitro and Evaluation of Helicobacter pylori Adhesion by Molecular Docking

24 Sept 2024

Abstract excerpt

Aims: We synthetized 10 hydroxylated and methoxylated chalcones and evaluated them targeting MMP-9 inhibition, looking for the rate of adhesion of H. pylori in gastric cells, and then, reduction of the inflammatory response as alternative therapeutic agents for controlling the infection. Background: Helicobacter pylori is a Gram-negative bacterium that chronically infects the human stomach, a risk factor for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39257142
DOI: 10.2174/0113816128327090240821101355

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