Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer.

doi:10.1371/journal.pone.0309844

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Article

Virulence gene polymorphisms in Shandong Helicobacter pylori strains and their relevance to gastric cancer.

PloS one - 1 Jan 2024

Xue Zhijing, Li Weijia, Ding Hailing, Pei Fengyan, Zhang Jianzhong, Gong Yanan, Fan Ruyue, Wang Fang, Wang Youjun, Chen Qing, Li Yanran, Yang Xinyu, Zheng Yan, Su Guohai

Abstract excerpt

BACKGROUND: Helicobacter pylori (H. pylori) virulence factors, particularly the cagA and vacA genotypes, play important roles in the pathogenic process of gastrointestinal disease. METHODS: The cagA and vacA genotypes of 87 H. pylori strains were determined by PCR and sequencing. The EPIYA and CM motif patterns were analyzed and related to clinical outcomes. We examined the associations between the virulence...

Topics

Helicobacter pylori
Stomach Neoplasms
Humans
Bacterial Proteins
Male
Middle Aged
Female
Helicobacter Infections
Antigens, Bacterial
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

China

Genotype

Aged

Virulence

Virulence Factors

Source

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Identifiers

PMID: 39250512
DOI: 10.1371/journal.pone.0309844
PMCID: PMC11383249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-39250512-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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