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[Concentration of gilteritinib in the cerebrospinal fluid of a patient with relapsed FLT3-ITD positive acute myeloid leukemia with optic nerve involvement].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2024

Suzuki Yuta, Kitawaki Toshio, Arai Yasuyuki, Nakagawa Shunsaku, Chonabayashi Kazuhisa, Nannya Yasuhito, Yamashita Kouhei, Ogawa Seishi, Takaori-Kondo Akifumi

Abstract excerpt

A 72-year-old woman with relapsed FLT3-ITD-positive acute myeloid leukemia was treated with gilteritinib and achieved complete remission with incomplete hematological recovery. However, two months later, she developed optic nerve infiltration and lost vision in her right eye while maintaining hematological remission on gilteritinib. Intrathecal injection of cytotoxic drugs reduced the number of blasts in the...

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PMID: 39231699
DOI: 10.11406/rinketsu.65.727

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