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Article

Assessment of transthyretin instability in patients with wild-type transthyretin amyloid cardiomyopathy.

Scientific reports - 3 Sept 2024

Iino Takuya, Nagao Manabu, Tanaka Hidekazu, Yoshikawa Sachiko, Asakura Junko, Nishimori Makoto, Shinohara Masakazu, Harada Amane, Watanabe Shunsuke, Ishida Tatsuro, Hirata Ken-Ichi, Toh Ryuji

Abstract excerpt

The pathophysiology of variant transthyretin (TTR) amyloidosis (ATTRv) is associated with destabilizing mutations in the TTR tetramer. However, why TTR with a wild-type genetic sequence misfolds and aggregates in wild-type transthyretin amyloidosis (ATTRwt) is unknown. Here, we evaluate kinetic TTR stability with a newly developed ELISA system in combination with urea-induced protein denaturation. Compared with...

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Identifiers

PMID: 39227655
DOI: 10.1038/s41598-024-71446-8
PMCID: PMC11371834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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