Article
Non-canonical olfactory pathway activation induces cell fusion of cervical cancer cells.
Neoplasia (New York, N.Y.) - 1 Nov 2024
Araki Keigo, Torii Takeru, Takeuchi Kohei, Kinoshita Natsuki, Urano Ryoto, Nakajima Rinka, Zhou Yaxuan, Kobayashi Tokuo, Hanyu Tadayoshi, Ohtani Kiyoshi, Ambe Kimiharu, Kawauchi Keiko
Abstract excerpt
Multinucleation occurs in various types of advanced cancers and contributes to their malignant characteristics, including anticancer drug resistance. Therefore, inhibiting multinucleation can improve cancer prognosis; however, the molecular mechanisms underlying multinucleation remain elusive. Here, we introduced a genetic mutation in cervical cancer cells to induce cell fusion-mediated multinucleation. The...
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