Error-induced extinction in a multi-type critical birth-death process.

Abstract excerpt

Extreme mutation rates in microbes and cancer cells can result in error-induced extinction (EEX), where every descendant cell eventually acquires a lethal mutation. In this work, we investigate critical birth-death processes with n distinct types as a birth-death model of EEX in a growing population. Each type-i cell divides independently ( i ) → ( i ) + ( i ) or mutates ( i ) → ( i + 1 ) at the same rate. The...

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