Defining and modeling dynamic spatial heterogeneity within tumor microenvironments

Abstract excerpt

Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which dynamically evolves during disease progression and after treatment. This constant flux in cell composition, phenotype, spatial relationships, and tissue properties poses significant challenges in accurately diagnosing and treating patients. Much of the complexity lies in unraveling the molecular changes in different tumor...

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• Cancer Cells and Metastasis
• Cell Image Analysis Techniques
• Single-cell and spatial transcriptomics