Article
Elucidating the causal nexus between antibody-mediated immunity and autoimmune diseases: Insights from bidirectional mendelian randomization, gene expression profiling, and drug sensitivity analysis.
International immunopharmacology - 5 Dec 2024
Chen Jiarui, Wei Cheng, Huang Shengsheng, Wu Shaofeng, He Rongqing, Chen Tianyou, Qin Xiaopeng, Wei Wendi, Qin Boli, Wu Songze, Zhu Jichong, Huang Chengqian, Feng Sitan, Zhou Zhongxian, Zhang Bin, Xue Jiang, Mo Sen, Zhou Chenxing, Qin Yingying, Zhan Xinli, Liu Chong
Abstract excerpt
OBJECTIVE: This study aimed to elucidate the causal relationships between antibodies and autoimmune diseases using Mendelian randomization (MR). METHODS: Data on 46 antibodies were obtained from genome-wide association studies (GWAS). Autoimmune disease data were sourced from the FinnGen consortium and the IEU OpenGWAS project. Inverse-variance weighted (IVW) analysis was the primary method, supplemented by...
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