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BPIFB3 Regulates Endoplasmic Reticulum Morphology To Facilitate Flavivirus Replication

21 Feb 2020

Abstract excerpt

Flaviviruses and other arthropod-transmitted viruses represent a widespread global health problem, with limited treatment options currently available. Thus, a better understanding of the cellular requirements for their infection is needed. Both DENV and ZIKV rely on expansion of the endoplasmic reticulum (ER) and the induction of autophagy to establish productive infections. However, little is known regarding the...

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PMID: 32102874
DOI: 10.1128/jvi.00029-20

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