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Identification of Penexanthone A as a Novel Chemosensitizer to Induce Ferroptosis by Targeting Nrf2 in Human Colorectal Cancer Cells

6 Aug 2024

Abstract excerpt

Ferroptosis has emerged as a potential mechanism for enhancing the efficacy of chemotherapy in cancer treatment. By suppressing nuclear factor erythroid 2-related factor 2 (Nrf2), cancer cells may lose their ability to counteract the oxidative stress induced by chemotherapy, thereby becoming more susceptible to ferroptosis. In this study, we investigate the potential of penexanthone A (PXA), a xanthone dimer...

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Ferroptosis and cancer prognosis
Genomics, phytochemicals, and oxidative stress
Glutathione Transferases and Polymorphisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39195474
DOI: 10.3390/md22080357

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