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Zika virus capsid protein closed structure modulates binding to host lipid systems

28 Aug 2024

Abstract excerpt

Zika virus (ZIKV), a mosquito-borne Flavivirus of international concern, causes congenital microcephaly in newborns and Guillain-Barré syndrome in adults. ZIKV capsid (C) protein, one of three key structural proteins, is essential for viral assembly and encapsidation. In dengue virus, a closely related flavivirus, the homologous C protein interacts with host lipid systems, namely intracellular lipid droplets, for...

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PMID: 39194132
DOI: 10.1002/pro.5142

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