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Article

Gene‒Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study.

Investigative ophthalmology & visual science - 1 Aug 2024

Yin Shanshan, Xu Liyan, Yang Kaili, Fan Qi, Gu Yuwei, Yin Chenchen, Zang Yonghao, Wang Yifan, Yuan Yi, Chang Anqi, Pang Chenjiu, Ren Shengwei

Abstract excerpt

Purpose: Keratoconus (KC), characterized by progressive corneal protrusion and thinning, is a complex disease influenced by the combination of genetic and environmental factors. The purpose of this study was to explore potential gene‒environment interaction between the calpastatin (CAST) gene and eye-rubbing in KC. Methods: A case-only study including 930 patients (676 patients with eye-rubbing and 254 patients...

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Source

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Identifiers

PMID: 39186261
DOI: 10.1167/iovs.65.10.36
PMCID: PMC11361386

Genes

CAST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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