Article
Natural brominated phenoxyphenols kill persistent and biofilm-incorporated cells of MRSA and other pathogenic bacteria.
Applied microbiology and biotechnology - 1 Jul 2020
van Geelen Lasse, Kaschani Farnusch, Sazzadeh Shabnam S, Adeniyi Emmanuel T, Meier Dieter, Proksch Peter, Pfeffer Klaus, Kaiser Markus, Ioerger Thomas R, Kalscheuer Rainer
Abstract excerpt
Due to a high unresponsiveness to chemotherapy, biofilm formation is an important medical problem that frequently occurs during infection with many bacterial pathogens. In this study, the marine sponge-derived natural compounds 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol and 3,4,6-tribromo-2-(2',4'-dibromophenoxy)phenol were found to exhibit broad antibacterial activity against medically relevant gram-positive and...
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