Article
Study on the Mutation of FⅨ Gene in 31 Patients with Type B Hemophilia.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis - 1 Jan 2000
Liu Danjuan, Guo Rongjie, Chen Min, Shi Bingbing, Weng Junting, Fu Zhifang
Abstract excerpt
Hemophilia B (HB) is an inherited bleeding disorder caused by defects in the FⅨ gene, leading to severe coagulation dysfunction. This study designed eight pairs of primers covering eight exons of the FⅨ gene and used PCR and DNA sequencing to detect FⅨ gene mutations in 31 HB patients. Sequencing results were compared with normal sequences using Chromas software on Blast to identify mutation sites. Findings...
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