Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy.

doi:10.1158/1078-0432.CCR-24-0154

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Article

Genotype-Directed Synthetic Cytotoxicity of ATR Inhibition with Radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 16 Dec 2024

Ng Victor, Sinha Sonali, Novaj Ardijana, Ma Jennifer, McDermott Niamh, Pei Xin, Longhini Ana Leda F, Grimsley Helen, Gardner Rui, Rosen Ezra, Powell Simon N, Pareja Fresia, Mandelker Diana, Khan Atif, Setton Jeremy, Roulston Anne, Morris Stephen, Koehler Maria, Lee Nancy, Reis-Filho Jorge, Riaz Nadeem

Abstract excerpt

PURPOSE: The importance of the DNA damage response in mediating effects of radiotherapy (RT) has galvanized efforts to target this pathway with radiosensitizers. Yet early clinical trials of this approach have failed to yield a benefit in unselected populations. We hypothesized that ataxia-telangiectasia mutated (Atm)-null tumors would demonstrate genotype-specific synergy between RT and an inhibitor of the DNA...

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Identifiers

PMID: 39109923
DOI: 10.1158/1078-0432.CCR-24-0154
PMCID: PMC11702853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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