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Article

Clinical and radiological response of Maffucci related enchondromas to mutant IDH1 inhibitor Ivosidenib.

Bone - 1 Nov 2024

Funck-Brentano Thomas, Cohen-Solal Martine, Ducray François, Mandonnet Emmanuel

Abstract excerpt

Ollier Disease (OD) and Maffucci syndrome (MS) is a rare bone disorder that affects the growth and development of the bones, with an estimated prevalence of 1 in 100,000 people. It is associated with somatic mosaicism of isocitrate dehydrogenase-1 (IDH1) or 2 (IDH2) pathogenic variants. Ivosidenib is indicated for the treatment of acute myeloid leukemia and locally advanced or metastatic cholangiocarcinoma and is...

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Identifiers

PMID: 39097182
DOI: 10.1016/j.bone.2024.117221

Genes

IDH1
IDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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