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Article

Genetic insights into the complexity of premature ovarian insufficiency.

Reproductive biology and endocrinology : RB&E - 2 Aug 2024

Nie Linhang, Wang Xiaojie, Wang Songyuan, Hong Zhidan, Wang Mei

Abstract excerpt

Premature Ovarian Insufficiency (POI) is a highly heterogeneous condition characterized by ovarian dysfunction in women occurring before the age of 40, representing a significant cause of female infertility. It manifests through primary or secondary amenorrhea. While more than half of POI cases are idiopathic, genetic factors play a pivotal role in all instances with known causes, contributing to approximately...

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Birth, Development, and Health
Genetic Predisposition to Disease
Mutation
Primary Ovarian Insufficiency
Reproductive Biology and Fertility

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PMID: 39095891
DOI: 10.1186/s12958-024-01254-2
PMCID: PMC11295921

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