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Assessment of cytotoxic and genotoxic effects of glyphosate-based herbicide on glioblastoma cell lines: Role of p53 in cellular response and network analysis.

Toxicology - 1 Nov 2024

Thiel Kelly Louise, da Silva Juliana, Wolfarth Micaele, Vanini Julia, Henriques João Antonio Pêgas, de Oliveira Iuri Marques, da Silva Fernanda Rabaioli

Abstract excerpt

Glyphosate, the world's most widely used herbicide, has a low toxicity rating despite substantial evidence of adverse health effects. Furthermore, glyphosate-based formulations (GBFs) contain several other chemicals, some of which are known to be harmful. Additionally, chronic, and acute exposure to GBFs among rural workers may lead to health impairments, such as neurodegenerative diseases and cancer. P53 is...

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Cell Survival
Comet Assay
DNA Damage
Dose-Response Relationship, Drug
Glioblastoma

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PMID: 39094917
DOI: 10.1016/j.tox.2024.153902

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