Article
First report of an Ivorian family with nonsyndromic hearing loss caused by GJB2 compound heterozygous variants.
Annals of human genetics - 1 Jul 2025
Toure Madoussou, Amalou Ghita, Raise Imane Ait, Mobio N'kan Max Ange, Malki Abderrahim, Barakat Abdelhamid
Abstract excerpt
The primary etiology of congenital hearing loss is attributed to genetic factors, with GJB2 identified as a pivotal gene across diverse ethnic groups. Additionally, nonsyndromic hearing loss is predominantly inherited in an autosomal recessive manner. We used Sanger sequencing to analyze GJB2 in 17 deaf children from 13 unrelated Ivory Coast families. One family had two children born with severe congenital...
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