Article
Team Science Approaches to Unravel Monogenic Parkinson's Disease on a Global Scale.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2024
Junker Johanna, Lange Lara M, Vollstedt Eva-Juliane, Roopnarain Karisha, Doquenia Maria Leila M, Annuar Azlina Ahmad, Avenali Micol, Bardien Soraya, Bahr Natascha, Ellis Melina, Galandra Caterina, Gasser Thomas, Heutink Peter, Illarionova Anastasia, Kanana Yuliia, Keller Sarmiento Ignacio J, Kumar Kishore R, Lim Shen-Yang, Madoev Harutyun, Mata Ignacio F, Mencacci Niccolò E, Nalls Mike A, Padmanabhan Shalini, Shambetova Cholpon, Solle J C, Tan Ai-Huey, Trinh Joanne, Valente Enza Maria, Singleton Andrew, Blauwendraat Cornelis, Lohmann Katja, Fang Zih-Hua, Klein Christine
Abstract excerpt
BACKGROUND: Until recently, about three-quarters of all monogenic Parkinson's disease (PD) studies were performed in European/White ancestry, thereby severely limiting our insights into genotype-phenotype relationships at a global scale. OBJECTIVE: To identify the multi-ancestry spectrum of monogenic PD. METHODS: The first systematic approach to embrace monogenic PD worldwide, The Michael J. Fox Foundation Global...
Topics
- Humans
- Parkinson Disease
- Genetic Predisposition to Disease
- Genetic Association Studies