Article
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model.
Protein & cell - 2 Dec 2024
Cai Xin-Yu, Wang Xin-Tai, Guo Jing-Wen, Xu Fang-Xiao, Ma Kuang-Yi, Wang Zhao-Xiang, Zhao Yue, Xie Wei, Schonewille Martijn, De Zeeuw Chris, Chen Wei, Shen Ying
Abstract excerpt
The cerebellum is heavily connected with other brain regions, sub-serving not only motor but also nonmotor functions. Genetic mutations leading to cerebellar dysfunction are associated with mental diseases, but cerebellar outputs have not been systematically studied in this context. Here, we present three dimensional distributions of 50,168 target neurons of cerebellar nuclei (CN) from wild-type mice and...
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