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An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF

5 Jul 2024

Abstract excerpt

IVF laboratories routinely adopt morphological pronuclear assessment at the zygote stage to identify abnormally fertilized embryos deemed unsuitable for clinical use. In essence, this is a pseudo-genetic test for ploidy motivated by the notion that biparental diploidy is required for normal human life and abnormal ploidy will lead to either failed implantation, miscarriage, or significant pregnancy complications,...

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PMID: 39043217
DOI: 10.1093/humrep/deae157

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