Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study.

doi:10.1200/JCO.24.00071

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Article

Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer: A Phase II Multicenter Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2024

Blakely Collin M, Urisman Anatoly, Gubens Matthew A, Mulvey Claire K, Allen Greg M, Shiboski Stephen C, Rotow Julia K, Chakrabarti Turja, Kerr D Lucas, Aredo Jacqueline V, Bacaltos Bianca, Gee Megan, Tan Lisa, Jones Kirk D, Devine W Patrick, Doebele Robert C, Aisner Dara L, Patil Tejas, Schenk Erin L, Bivona Trever G, Riess Jonathan W, Coleman Melissa, Kratz Johannes R, Jablons David M

Abstract excerpt

PURPOSE: To assess the safety and efficacy of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib as neoadjuvant therapy in patients with surgically resectable stage I-IIIA EGFR-mutated non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: This was a multi-institutional phase II trial of neoadjuvant osimertinib for patients with surgically resectable stage I-IIIA...

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PMID: 39028931
DOI: 10.1200/JCO.24.00071
PMCID: PMC11379363

Genes

EGFR
RBM10
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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