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Low-Grade Gliomas: A New Mutation, New Targeted Therapy, and Many Questions.

Neurology - 13 Aug 2024

Schiff David

Abstract excerpt

The discovery in 2008 that many adult gliomas harbor a hitherto unknown mutation in the metabolic gene isocitrate dehydrogenase (IDH) initiated revolutionary advances in our understanding of the biology, and correspondingly our classification, of gliomas. IDH mutations are found in most nonglioblastoma adult gliomas and portend a better prognosis. Massive efforts have unraveled many of the pleiotropic cellular...

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PMID: 39008801
DOI: 10.1212/WNL.0000000000209688

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