Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer

8 Jul 2024

Abstract excerpt

Cisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is available on the regulation of cisplatin resistance and the underlying mechanisms require elucidation. Here, we detected that downregulation of the tumor suppressor, PPP2R2B (a serine/threonine protein phosphatase 2 A regulatory subunit), in BC promoted cell proliferation and migration....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38976080
DOI: 10.1007/s00018-024-05320-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancerPMID 38976080Read ↗

KIF15 promotes bladder cancer proliferation via the MEK–ERK signaling pathwaySemantic proximity Read ↗

ISG15 silencing increases cisplatin resistance via activating p53-mediated cell DNA repairSemantic proximity Read ↗

High PRMT5 expression is associated with poor overall survival and tumor progression in bladder cancerSemantic proximity Read ↗

ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7Semantic proximity Read ↗

LncSNHG14 promotes the development and progression of bladder cancer by targeting miRNA-150-5p.Semantic proximity Read ↗

LncRNA PVT1 Promotes Bladder Cancer Progression by Forming a Positive Feedback Loop With STAT5BSemantic proximity Read ↗

PBX1 Participated in Estrogen Mediated Bladder Cancer Progression and Chemo-Resistance through Affecting Estrogen ReceptorsSemantic proximity Read ↗

MicroRNA-30c-5p arrests bladder cancer G2/M phase and suppresses its progression by targeting PRC1-mediated blocking of CDK1/Cyclin B1 axisSemantic proximity Read ↗

Prognostic and chemotherapeutic response prediction by proliferation essential gene signature: Investigating POLE2 in bladder cancer progression and cisplatin resistanceSemantic proximity Read ↗

BTG2 is a tumor suppressor gene upregulated by p53 and PTEN in human bladder carcinoma cells.Semantic proximity Read ↗

Effects and mechanisms of AMIGO2 in proliferation, migration and drug resistance of bladder cancerSemantic proximity Read ↗

IMP2 drives chemoresistance by repressing cisplatin-induced apoptosis and ferroptosis via activation of IPO4 and SLC7A11 under hypoxia in bladder cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.