Article
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer.
Science advances - 13 Oct 2023
Mohanty Atish, Nam Arin, Srivastava Saumya, Jones Jeff, Lomenick Brett, Singhal Sharad S, Guo Linlin, Cho Hyejin, Li Aimin, Behal Amita, Mirzapoiazova Tamara, Massarelli Erminia, Koczywas Marianna, Arvanitis Leonidas D, Walser Tonya, Villaflor Victoria, Hamilton Stanley, Mambetsariev Isa, Sattler Martin, Nasser Mohd W, Jain Maneesh, Batra Surinder K, Soldi Raffaella, Sharma Sunil, Fakih Marwan, Mohanty Saswat Kumar, Mainan Avijit, Wu Xiwei, Chen Yihong, He Yanan, Chou Tsui-Fen, Roy Susmita, Orban John, Kulkarni Prakash, Salgia Ravi
Abstract excerpt
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells correlated with increased expression of integrin β4 (ITGB4), a component of the focal adhesion complex. Silencing ITGB4 in tolerant cells improved sotorasib sensitivity, while overexpressing ITGB4 enhanced tolerance to sotorasib by supporting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.