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Article

Causal link between hypothyroidism and gastric cancer risk: insights gained through multivariable Mendelian randomization and mediation analysis.

Frontiers in endocrinology - 1 Jan 2024

Zhang Tianyue, Qiao Jie, Wang Yuanyou, Zhou Yinying, Jabbar Abdl Sattar Hamoudi Hammza, Hendi Mhd Alaa Al, Wang Jun

Abstract excerpt

Background: Gastric cancer (GC) is the third leading cause of cancer death worldwide, and hypothyroidism has been identified as a potential influencing factor. Despite known associations between hypothyroidism and various cancers, the causal link between hypothyroidism and GC and potential mediators of this relationship remains unclear. This study aimed to clarify these relationships using Mendelian randomization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38904039
DOI: 10.3389/fendo.2024.1388608
PMCID: PMC11186985

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