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Article

Rewiring the Sex-Determination Pathway During the Evolution of Self-Fertility.

Molecular biology and evolution - 1 Jun 2024

Shen Yongquan, Lin Shin-Yi, Harbin Jonathan, Amin Richa, Vassalotti Allison, Romanowski Joseph, Schmidt Emily, Tierney Alexis, Ellis Ronald E

Abstract excerpt

Although evolution is driven by changes in how regulatory pathways control development, we know little about the molecular details underlying these transitions. The TRA-2 domain that mediates contact with TRA-1 is conserved in Caenorhabditis. By comparing the interaction of these proteins in two species, we identified a striking change in how sexual development is controlled. Identical mutations in this domain...

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Identifiers

PMID: 38880992
DOI: 10.1093/molbev/msae101
PMCID: PMC11180601

Genes

TRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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