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Article

Identification of the cytoplasmic DNA-Sensing cGAS-STING pathway-mediated gene signatures and molecular subtypes in prostate cancer.

BMC cancer - 14 Jun 2024

Yang Jie, Xu Zihan, Zheng Weitao, Li Yifan, Wei Qiang, Yang Lu

Abstract excerpt

BACKGROUND: Considering the age relevance of prostate cancer (PCa) and the involvement of the cGAS-STING pathway in aging and cancer, we aim to classify PCa into distinct molecular subtypes and identify key genes from the novel perspective of the cGAS-STING pathway. It is of significance to guide personalized intervention of cancer-targeting therapy based on genetic evidence. METHODS: The 430 patients with PCa...

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Identifiers

PMID: 38877472
DOI: 10.1186/s12885-024-12492-3
PMCID: PMC11179326

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