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Comparison of plasma and blood cell samples in metagenomic next-generation sequencing for identification of the causative pathogens of fever

21 May 2024

Abstract excerpt

Background: Metagenomic next-generation sequencing (mNGS) of plasma DNA has become an attractive diagnostic method for infectious diseases; however, the rate of false-positive results is high. This study aims to evaluate the diagnostic accuracy of mNGS in plasma versus blood cell samples for immunocompromised children with febrile diseases. Methods: The results of conventional microbiological test (CMT) and mNGS...

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PMID: 38841453
DOI: 10.1016/j.heliyon.2024.e31677

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