Article
A cellulose synthesis inhibitor affects cellulose synthase complex secretion and cortical microtubule dynamics.
Plant physiology - 2 Sept 2024
Renou Julien, Li Deqiang, Lu Juan, Zhang Baocai, Gineau Emilie, Ye Yajin, Shi Jianmin, Voxeur Aline, Akary Elodie, Marmagne Anne, Gonneau Martine, Uyttewaal Magalie, Höfte Herman, Zhao Yang, Vernhettes Samantha
Abstract excerpt
P4B (2-phenyl-1-[4-(6-(piperidin-1-yl) pyridazin-3-yl) piperazin-1-yl] butan-1-one) is a novel cellulose biosynthesis inhibitor (CBI) discovered in a screen for molecules to identify inhibitors of Arabidopsis (Arabidopsis thaliana) seedling growth. Growth and cellulose synthesis inhibition by P4B were greatly reduced in a novel mutant for the cellulose synthase catalytic subunit gene CESA3 (cesa3pbr1)....
Topics
- Glucosyltransferases
- Microtubules
- Arabidopsis
- Cellulose
- Arabidopsis Proteins
- Mutation
- Seedlings
- Cell Membrane
- Pyridazines
- Cell Wall
- Enzyme Inhibitors
- Benzamides