Phase II Efficacy and Safety of 80 mg Osimertinib in Patients With Leptomeningeal Metastases Associated With Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer (BLOSSOM).

doi:10.1200/JCO.24.00708

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Phase II Efficacy and Safety of 80 mg Osimertinib in Patients With Leptomeningeal Metastases Associated With Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer (BLOSSOM).

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2024

Park Sehhoon, Baldry Richard, Jung Hyun Ae, Sun Jong-Mu, Lee Se-Hoon, Ahn Jin Seok, Kim Yu Jung, Lee Youngjoo, Kim Dong-Wan, Kim Sang-We, Lee Ki Hyeong, Lee Won Jae, Choi Jung Won, Chong Kyuha, Lee Jung-Il, Gwon So-Hyeon, Son Nak-Hoon, Ahn Myung-Ju

Abstract excerpt

PURPOSE: Leptomeningeal metastases (LMs) exhibit a high incidence in patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) post-treatment with first- or second-generation EGFR tyrosine kinase inhibitors (TKIs). This investigation evaluates the efficacy, safety, and pharmacokinetics of 80 mg once daily osimertinib in patients with LMs resistant to prior first- or...

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PMID: 38828959
DOI: 10.1200/JCO.24.00708
PMCID: PMC11315406

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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