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Article

Osimertinib for Patients With Leptomeningeal Metastases Associated With EGFR T790M-Positive Advanced NSCLC: The AURA Leptomeningeal Metastases Analysis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2020

Ahn Myung-Ju, Chiu Chao-Hua, Cheng Ying, Han Ji-Youn, Goldberg Sarah B, Greystoke Alastair, Crawford Jeffrey, Zhao Yanqiu, Huang Xiangning, Johnson Martin, Vishwanathan Karthick, Yates James W T, Brown Andrew P, Mendoza-Naranjo Ariadna, Mok Tony

Abstract excerpt

INTRODUCTION: Osimertinib has shown promising activity in patients with leptomeningeal metastases (LMs) of EGFR-positive NSCLC at 160 mg once daily (qd) (BLOOM; NCT02228369). We report LM activity with osimertinib (80 mg qd) in a retrospective analysis of studies across the AURA program (AURA extension, AURA2, AURA17, and AURA3). METHODS: Patients with EGFR T790M-positive advanced NSCLC and progression after...

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PMID: 31887431
DOI: 10.1016/j.jtho.2019.12.113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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