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Article

Standard-dose osimertinib for refractory leptomeningeal metastases in T790M-positive EGFR-mutant non-small cell lung cancer.

British journal of cancer - 1 Jan 2018

Nanjo Shigeki, Hata Akito, Okuda Chiyuki, Kaji Reiko, Okada Hideaki, Tamura Daisuke, Irie Kei, Okada Hiroshi, Fukushima Shoji, Katakami Nobuyuki

Abstract excerpt

BACKGROUND: Osimertinib demonstrated promising efficacy for refractory leptomeningeal metastases (LM) in preclinical data and a clinical study at 160 mg, but there is limited data for the standard 80 mg dose. METHODS: T790M-positive patients with suspected LM after classical epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) failure were enroled. RESULTS: We investigated 13 patients (5...

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Identifiers

PMID: 29190637
DOI: 10.1038/bjc.2017.394
PMCID: PMC5765232

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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