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Human neutralizing antibodies target a conserved lateral patch on H7N9 hemagglutinin head

27 May 2024

Abstract excerpt

Avian influenza A virus H7N9 causes severe human infections with >30% fatality. Currently, there is no H7N9-specific prevention or treatment for humans. Here, from a 2013 H7N9 convalescent case in Hong Kong, we isolate four hemagglutinin (HA)-reactive monoclonal antibodies (mAbs), with three directed to the globular head domain (HA1) and one to the stalk domain (HA2). Two clonally related HA1-directed mAbs,...

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PMID: 38802413
DOI: 10.1038/s41467-024-48758-4

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