Article
SNP and Structural Study of the Notch Superfamily Provides Insights and Novel Pharmacological Targets against the CADASIL Syndrome and Neurodegenerative Diseases.
Genes - 23 Apr 2024
Papageorgiou Louis, Papa Lefteria, Papakonstantinou Eleni, Mataragka Antonia, Dragoumani Konstantina, Chaniotis Dimitrios, Beloukas Apostolos, Iliopoulos Costas, Bongcam-Rudloff Erik, Chrousos George P, Kossida Sofia, Eliopoulos Elias, Vlachakis Dimitrios
Abstract excerpt
The evolutionary conserved Notch signaling pathway functions as a mediator of direct cell-cell communication between neighboring cells during development. Notch plays a crucial role in various fundamental biological processes in a wide range of tissues. Accordingly, the aberrant signaling of this pathway underlies multiple genetic pathologies such as developmental syndromes, congenital disorders,...
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