Article
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia.
Nature - 24 Oct 1996
Joutel A, Corpechot C, Ducros A, Vahedi K, Chabriat H, Mouton P, Alamowitch S, Domenga V, Cécillion M, Marechal E, Maciazek J, Vayssiere C, Cruaud C, Cabanis E A, Ruchoux M M, Weissenbach J, Bach J F, Bousser M G, Tournier-Lasserve E
Abstract excerpt
Stroke is the third leading cause of death, and vascular dementia the second cause of dementia after Alzheimer's disease. CADASIL (for cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) causes a type of stroke and dementia whose key features include recurrent subcortical ischaemic events and vascular dementia and which is associated with diffuse white-matter abnormalities...
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